This guitar part is harder than the backing guitar, but great fun to play once you master it. The lead comes in here with that signature Bond riff. It's nice single notes, and the trick to getting it fast is in the picking.
Use downstrokes mostly, except for that fast 3rd note, where an upstroke gives you the extra speed required. Do this each time that riff repeats along the Low E string...even though the notes slightly change along that string, the picking remains the same each time.
Practice this (where it is all along just the Low E string) until you get comfortable with it. Then start working on the string skipping part at the end of this tune segment. The trick to that part is to quickly move your first finger to the first fret of the D string as the previous Low E note is being played. There's not a lot of time to do that, so this will take practice.
The next part of the melody is trickier for your fretboard hand because there are some mutes, vibrato and pull offs used. However, the picking is a bit easier for your other hand allowing you to concentrate more on getting the fretboard notes right. Just break it up into managable chunks and work at it bit by bit.
At this point the backing guitar plays along with the lead guitar. Both guitars play exactly the same smooth jazz style melody, however the lead guitar plays the notes 1 octave higher. You can hear both guitars in the ActionTab. Don't let the other guitar put you off. Stay tight to the notes shown in this ActionTab and once you get consistent with the timing, work at playing along with the normal speed audio.
The lead also plays a little lick for the ending. If you can play the rest of the tune so far, this should give you no real trouble. Just be aware that when the muting is used, its purpose is to kill the notes before moving to the next note. In this kind of tune the muting technique helps to add a bit of drama. The muting means your fingers must linger a little bit on the strings (to get that brief pause) before you play the next note. It also means that open strings need to be muted (like here), even though the open D note is not actually fretted with a finger in the first place, it needs to be muted by one.