This is one of Marilyn Manson's best known songs, and one of the easiest to learn. The majority of the song is played with just 2 powerchords and the rest is rhythmic muting. The only issue is that the song is in Drop D tuning. If you are in standard tuning, that means lowering the Lowest string by 2 notes. The quick way to do it is play your middle D string, and then downtune your Low E until it matches.

Drop D Tuning - Low D : A : D : G : B : E

Intro - Mute the strings by resting your finger (or fingers) across the strings. It doesn't matter too much where you mute the strings, just as long as you don't strike natural harmonics (avoid the 5th fretwire in particular). Muting around the 3rd fret is pretty safe from harmonics, plus it leaves your fingers in place for the later riffs.

Strike the strings in batches of 5 with a brief pause between each batch. If you are getting notes sounding out then use less pressure with your fingers holding the strings. You can also palm mute the strings with your strumming hand to help control the sound.

Riff 1 - Before the vocals start the intro riff changes to bring in powerchords. The muted strikes here are done on higher strings, but really it doesn't matter much where you mute here. The important thing is getting the powerchords in at the right time.

Riff 2 - This is the main (sort-of) chorus riff. It is short and repetitive. Keep playing between the Powerchord at fret 6 and open strings until the last time, where the 1st finger is used at fret 3. The riff repeats each time after that. Listen a few times and you'll get it.

Riff 3 - Go back to muting, like during the intro. However the rhythm is a little different this time. After these 3 muted strokes just rinse and repeat.

Simple Lick - The keyboard does weird notes here, meanwhile the guitar plays this easy descending lick.

Riff 4 - After a few repeats of riff 2 (the chorusy riff), the guitar goes silent except to repeat this little chunky riff at the end of each drum cycle.

Outro - The only new riff comes at the end of the song during the outro. It is just a variation of Riff 2. It starts the same way, but ends with this section each time before repeating.